Bishop Anthony was born Richard Anthony Michaels on the feast day of St. Anthony the Great (January 17) to parents Anthony and Gertrude Michaels and was baptized at St. Symeon the Stylite Antiochian Orthodox Christian Church in Ironwood, Mich. Rick was raised with his sister, Joanne, and brother, Craig. The Orthodox church in Ironwood is pan-Orthodox and thus included all ethnic Orthodox communities in the city. Bishop Anthony's father is Lebanese and his mother is Serbian. As a teenager he was active in all varsity athletics at Ironwood High School, including his role as the starting quarterback of his football team.

Bishop Anthony attended the University of Michigan, where he received his B.A. in Literature, Science and the Arts, earning a double major in History and English Literature. Following his university degree, he attended St. Vladimir's Orthodox Theological Seminary in Yonkers, N.Y., where he earned a Master of Divinity degree and graduated as Valedictorian of his class. Besides English, he has a reading knowledge of biblical Greek and continues to learn Arabic, at the request of His Eminence Metropolitan Philip of blessed memory.

His Grace taught modern philosophy at Gogebic Community College in Ironwood, Mich., before becoming a pastoral assistant and youth director at St. Nicholas Antiochian Orthodox Christian Church in Montreal, Quebec for two years. He and fellow seminarian Fr. Patrick Kinder of blessed memory held positions of youth coordinators at St. George Antiochian Orthodox Christian Church in Akron, Ohio, while they toured the country giving concerts and retreats as part of the musical group KERYGMA. Fr. Anthony also spent two years based in Nashville, Tenn. at St. Ignatius Antiochian Orthodox Church in Franklin, recording for KERYGMA with Fr. Patrick and Fr. Michael (Alan) Shanbour. He lectured extensively in North America, speaking to youth groups and church retreats for various jurisdictions besides his own.

His Grace was ordained to the Holy Diaconate on September 18, 2004. The next day he was ordained to the Holy Priesthood on September 19, 2004 at St. George Antiochian Orthodox Church in West St. Paul, Minn., under the pastorate of the Very Rev. John Khoury of blessed memory, and by the laying on of hands of Bishop Antoun. He was able to serve his home parish for seven months before being assigned to lead the faithful of St. John Chrysostom Church in Fort Wayne, Ind.

Bishop Anthony inspired and oversaw the design and construction of the new church facilities at St. John Chrysostom Church in Fort Wayne. On the sixth anniversary of his ordination to the Holy Priesthood, he had the great honor of hosting Metropolitan Philip for the consecration of the new church on September 19, 2010, at which time he was elevated to the dignity of Archimandrite by the laying on of hands of the Metropolitan. He was subsequently appointed dean of the Indiana Deanery by Metropolitan Philip.

On Sunday, December 11, 2011, Bishop Anthony was consecrated as Auxiliary of the Diocese of Toledo and the Midwest for the Antiochian Orthodox Christian Archdiocese of North America. The consecration took place at the Church of the Dormition of the Theotokos in the Patriarchal Monastery of Our Lady of Balamand, Balamand, Lebanon. After over twelve years of faithful ministry overseeing the Diocese of Toledo, His Eminence Metropolitan Saba announced on June 10, 2024 that Bishop Anthony had accepted a new assignment to serve as the Bishop of the Diocese of Los Angeles and the West, beginning August 1, 2024.